abstract：BACKGROUND:The aim of this work was to investigate the benefit of basiliximab induction therapy in living-related-donor kidney transplantation. METHODS:One hundred adult recipients of a first kidney allograft were randomized into two treatment groups, one to receive basiliximab and the second as a control. All patient...

journal_title：Journal of nephrology

authors： Sheashaa HA,Bakr MA,Ismail AM,Sobh MA,Ghoneim MA

更新日期：2003-05-01 00:00:00

abstract：:Hereditary systemic amyloidosis is caused by deposition of genetically variant proteins as amyloid fibrils. The types that present with renal disease are usually associated with mutations in the genes for either apolipoprotein AI, apolipoprotein AII, lysozyme or fibrinogen A alpha-chain. These diseases are inherited i...

journal_title：Journal of nephrology

authors： Hawkins PN

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Previously we have demonstrated anabolic effects and improved functional status after growth hormone (GH)-therapy in elderly patients in chronic hemodialysis. The aim of this study is to elucidate the effects of GH-therapy on lipid profiles, blood pressure and bone metabolism. METHODS:Twenty patients, mean ...

journal_title：Journal of nephrology

authors： Viidas U,Johannsson G,Mattson-Hultén L,Ahlmén J

更新日期：2003-03-01 00:00:00

abstract：:The combination of hypomagnesemia and hypocalciuria is the phenotypic signature of two distinct genetic renal tubular transport disorders: Gitelman's syndrome and autosomal dominant isolated renal magnesium wasting. In the past 5 years the genetic defects underlying these disorders have been elucidated through positio...

journal_title：Journal of nephrology

authors： Knoers NV,de Jong JC,Meij IC,Van Den Heuvel LP,Bindels RJ

更新日期：2003-03-01 00:00:00

abstract：:Over the last two decades, several studies have reported a high prevalence of cardiovascular disease in patients with end-stage renal disease (ESRD). This population usually presents both the traditional and non-traditional risk factors for atherosclerosis. Inflammation as well as impaired nitric oxide production are ...

journal_title：Journal of nephrology

authors： Rattazzi M,Puato M,Faggin E,Bertipaglia B,Grego F,Pauletto P

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Functional failure of the peritoneal membrane is the most serious problem in long-term continuous ambulatory peritoneal dialysis (CAPD). Transforming growth factor-beta (TGF-ss) is one of the key mediators of fibrosis in some organs, and is thought to be involved in peritoneal alterations. In this study, we ...

journal_title：Journal of nephrology

authors： Naiki Y,Maeda Y,Matsuo K,Yonekawa S,Sakaguchi M,Iwamoto I,Hasegawa H,Kanamaru A

更新日期：2003-01-01 00:00:00

abstract：:Clinical immunology laboratories play an essential role in diagnosis and monitoring of systemic lupus erythematosus (SLE). To obtain the best results in terms of diagnostic performance and clinical usefulness, the following recommendations should be fulfilled: Indirect immunofluorescence on Hep-2 cells remains the met...

journal_title：Journal of nephrology

authors： Sinico RA,Bollini B,Sabadini E,Di Toma L,Radice A

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Stenoses of vascular accesses are leading factors limiting access survival. Besides physical examination, screening of access stenoses is based mainly on the "dysfunction hypothesis", which states that progressive stenosis causes graft dysfunction, such as decreased flow. We tested whether Doppler ultrasonog...

journal_title：Journal of nephrology

authors： Malik J,Slavikova M,Malikova H,Maskova J

更新日期：2002-11-01 00:00:00

abstract：:We report the first documented case of X-linked chronic granulomatous disease (CGD) in association with IgA nephropathy in a 22 year old male with multiple soft tissue abscesses. The case highlights the potential role of staphylococcal infections in the pathogenesis of IgA nephropathy and suggests the hypothesis that ...

journal_title：Journal of nephrology

authors： Narsipur SS,Shanley PF

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Different mitogens are involved in the pathogenesis of kidney damage after subtotal nephrectomy. One of them, TGF-beta, controls mesangial cell proliferation and interstitial fibrosclerosis. The transduction of the TGF-beta signal is controlled by intracellular signalling molecules such as Ras G monomeric pr...

journal_title：Journal of nephrology

authors： Bernardini N,Cupisti A,Mattii L,Segnani C,Dolf A,Barsotti M,Barsotti G

更新日期：2002-09-01 00:00:00

abstract：:Primary renal non-Hodgkin's lymphoma is very rare in childhood. A six-year-old boy presented with bilateral non-obstructive multinodular nephromegaly and renal failure. Percutaneous needle biopsy showed large-cell lymphoma. The patient was started on chemotherapy. A right nephrectomy was done when systemic hypertensio...

journal_title：Journal of nephrology

authors： Karadeniz C,Oguz A,Ataoglu O,Citak C,Buyan N,Pinarli G,Ozkaya O,Kapucu O

更新日期：2002-09-01 00:00:00

abstract：:Chronic hypotension, defined by a systolic blood pressure < 100 mmHg in the interdialytic period, affects 5-10% of hemodialysis patients, and is more prevalent among patients on long-term hemodialysis. This complication requires a substantial amount of medical and nursing care before and during dialysis to control its...

journal_title：Journal of nephrology

authors： Cases A,Coll E

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Lactic acidosis is a widely recognized, though rare, side effect of metformin. This paper describes five patients admitted to Chang Gung Memorial Hospital from 1 September 1998 to 31 May 2001 suffering severe lactic acidosis caused by metformin, and reviews the literature. PATIENTS:Five cases diagnosed as h...

journal_title：Journal of nephrology

authors： Chang CT,Chen YC,Fang JT,Huang CC

更新日期：2002-07-01 00:00:00

abstract：:Various opinions have been presented about the influence of age on the health-related quality of life (HRQOL) of patients on renal replacement therapy (RRT). Some authors sustain that age worsens HRQOL, while others show the opposite. It has been seen that a psychological adjustment occurs with aging, even when chroni...

journal_title：Journal of nephrology

authors： Ortega F,Rebollo P

更新日期：2002-05-01 00:00:00

abstract：:We followed up 128 patients with crescentic glomerulonephritis (CGN), having sufficient clinical and histopathological data for a mean period of 34 +/- 28 months. There were 49 males and 79 females, mean age 22.7 +/- 14 years. We studied the effects of clinical, laboratory and histopathological parameters on kidney fu...

journal_title：Journal of nephrology

authors： El-Husseini AA,Moustafa FE,Fouda MA,Sobh MA

更新日期：2002-05-01 00:00:00

abstract：:The collecting duct is responsible for the final secretion or reabsorption of protons and bicarbonate, respectively. Approximately 2% of the total filtered bicarbonate is reabsorbed in this segment. At least two different types of cells are involved in the transport of protons and bicarbonate, namely, type A and B int...

journal_title：Journal of nephrology

authors： Wagner CA,Geibel JP

更新日期：2002-03-01 00:00:00

abstract：:Recent molecular cloning experiments have identified the existence of four NBC isoforms (NBC1, 2, 3 and 4) and two NBC-related proteins AE4 and NCBE (Anion Exchanger 4 and Sodium-dependent Chloride-Bicarbonate Exchanger). Except for AE4 which does not transport Na, all are presumed to mediate the cotransport of Na+ an...

journal_title：Journal of nephrology

authors： Soleimani M

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Chronic renal failure (CRF) is associated with a tendency to atherosclerosis due to the enhanced oxidative stress and insufficient antioxidant enzyme activities such as superoxide dismutase (SOD), catalase (CAT) and paraoxonase (PON 1), together with abnormalities in lipid parameters. We determined the in vi...

journal_title：Journal of nephrology

authors： Ak G,Ozgönül M,Sözmen EY,Aslan SL,Sözmen B

更新日期：2002-03-01 00:00:00

abstract：:Hypertension is a risk factor for cardiovascular and renal organ damage. Environmental conditions affect the development of high blood pressure (BP), although genetic influences are also important. Current international guidelines recommend reducing dietary sodium to no more than 100 mmol (about 2.4 g sodium or approx...

journal_title：Journal of nephrology

authors： Milan A,Mulatero P,Rabbia F,Veglio F

更新日期：2002-01-01 00:00:00

abstract：:Cell-to-cell signal exchange during antigen presentation deeply influences the profile and extent of the immune response. Together with the TCR/MHC-mediated signal, accessory signals are provided to the T cell by the antigen-presenting cell (APC), through specific receptor-ligand interactions that represent indispensa...

journal_title：Journal of nephrology

authors： Biancone L,Deambrosis I,Camussi G

更新日期：2002-01-01 00:00:00

abstract：:Evidence-based medicine provides tools to evaluate dialysis outcomes by integrating knowledge obtained from interventional and observational studies. This is illustrated in relation to three important topics: dialysis membranes, dialysis dose and anemia. Clinical trials and observational evidence support each other in...

journal_title：Journal of nephrology

authors： Locatelli F,Andrulli S,D'Amico M

更新日期：2001-11-01 00:00:00

abstract：:Hyperlipidaemia complicating the nephrotic syndrome is characterised by elevated levels of total and LDL cholesterol, often with hypertriglyceridaemia and low HDL cholesterol levels. The underlying mechanisms are complex but involve abnormalities of both lipoprotein synthesis and catabolism. Experience to date suggest...

journal_title：Journal of nephrology

authors： Wheeler DC

更新日期：2001-11-01 00:00:00

abstract：:Although several in vitro studies and clinical observations suggest that ACE-inhibitors (ACE-I) are a promising treatment for IgA nephropathy (IgAN), meta-analysis of published data is not yet conclusive. Therefore, a European double-blinded, prospective, randomized therapeutic trial was designed to evaluate ACE-I tre...

journal_title：Journal of nephrology

authors： Coppo R,Chiesa M,Peruzzi L,Amore A

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:The patient characteristics and course of HlV/AIDS-associated nephropathy (HIVAN) are presented for a national sample of end-stage renal disease (ESRD). METHODS:375,152 patients in the United States Renal Data System were initiated on ESRD therapy between 1 January 1992 and 30 June 1997 and analyzed in an h...

journal_title：Journal of nephrology

authors： Abbott KC,Hypolite I,Welch PG,Agodoa LY

更新日期：2001-09-01 00:00:00

abstract：:Cutaneous periarteritis nodosa (PAN) is a clinical feature characterized by chronic, benign course; its pathogenesis is unknown. In patients submitted to renal transplantation cutaneous PAN is a rare complication. We report a case of cutaneous PAN associated with the reappearance of hepatitis B antigen 16 years after ...

journal_title：Journal of nephrology

authors： Bedani PL,Bergami M,Cavazzini PL,Strumia R,Morelli MC,Stabellini G,Gilli P

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that bleeding times have positive predictive values of only 5% for perioperative bleeding in unselected populations. Nevertheless, performing bleeding times prior to all renal biopsies is common in nephrology practice. METHODS:We report complications of 112 renal biopsies done at...

journal_title：Journal of nephrology

authors： Stiles KP,Hill C,LeBrun CJ,Reinmuth B,Yuan CM,Abbott KC

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Since dialysis has brought long-term survival to uremic patients, we can now speculate on more subtle problems derived from imbalance or sub-optimal regulation of some elements such as trace metals. We focused on the rubidium (Rb) status in dialysis patients (HD), as concerns about its possible deficiency ha...

journal_title：Journal of nephrology

authors： Canavese C,DeCostanzi E,Branciforte L,Caropreso A,Nonnato A,Pietra R,Fortaner S,Jacono F,Angelini G,Gallieni M,Fop F,Sabbioni E

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Congenital nephrotic syndrome is an uncommon disorder that may be caused by several diseases. These may be inherited, sporadic, acquired or part of a general malformation syndrome. METHODS:We reviewed the clinical characteristics, pathologic findings, and results of medical management in 30 infants who pres...

journal_title：Journal of nephrology

authors： Hamed RM,Shomaf M

更新日期：2001-03-01 00:00:00

abstract：:In 1998, the Italian Ministry of Health urged the Italian Society of Nephrology (SIN) to draft recommendations for uniform decision-making procedures in the field of dialysis. In accordance with the Ministry's specifications, at the time the Society approved diagnostic protocols regarding clinical questions, but witho...

journal_title：Journal of nephrology

authors： Buzzi F,Cecioni R,Di Paolo M,National Task Force for Bioethics in Nephrology.

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Severe hyperhomocysteinemia is common in hemodialysis patients, who also present a dramatic increase in plasma concentrations of sulfate, one of the main products of methionine and cysteine catabolism. The aim of this study was to verify the relationship between high plasma sulfate levels and cysteine or hom...

journal_title：Journal of nephrology

authors： Brunetti M,Terracina L,Timio M,Saronio P,Capodicasa E

更新日期：2001-01-01 00:00:00

abstract：:Percutaneous transluminal angioplasty of the renal artery (PTRA) has been increasingly used over the past 20 years for treating renovascular hypertension (RVH). From the experience gathered so far it is justified to state that this technique is the first choice for patients with fibromuscular renal artery stenosis (RA...

journal_title：Journal of nephrology

authors： Morganti A

更新日期：2000-11-01 00:00:00

abstract：:Membranous glomerulopathy (MGN) is a frequent cause for nephrotic syndrome in adults. In this overview, the basic pathogenic features of Heymann nephritis, a "classical" model of MGN in rats, are compared with those of human MGN. While the pathogenic antigen(s) of rat Heymann nephritis (the polyspecific receptor prote...

journal_title：Journal of nephrology

authors： Kerjaschki D

更新日期：2000-11-01 00:00:00

abstract：AIMS:To examine the distribution of bone mineral density (BMD) in different histological groups of renal osteodystrophy. PATIENTS:We prospectively studied 62 patients, 41 men and 21 women, aged 57+/-11.5 years, who had been on hemodialysis for 60+/-55 months. The women had been amenorrheic for 13+/-4 years and 7 patie...

journal_title：Journal of nephrology

authors： Gerakis A,Hadjidakis D,Kokkinakis E,Apostolou T,Raptis S,Billis A

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Patients with IgA nephropathy and histological vasculitic/crescentic lesions have a poor prognosis. We performed a retrospective study to assess whether treatment with steroids and immunosuppressants would preserve renal function by healing these lesions and thereby prevent progression to glomerular sclerosi...

journal_title：Journal of nephrology

authors： Harper L,Ferreira MA,Howie AJ,Savage CO,Richards NT,Michael J,Adu D

更新日期：2000-09-01 00:00:00

abstract：:That systemic hypertension is involved in the progression of human renal disease is mostly suggested by the way anti-hypertensive treatment affects the course of the disease. Clinical evidence has been obtained from observational studies as well as from studies of dietary protein restriction. In addition, several tria...

journal_title：Journal of nephrology

authors： Maschio G,Oldrizzi L,Marcantoni C,Rugiu C

更新日期：2000-05-01 00:00:00

abstract：:Chronic renal failure (CRF) is associated with a 20-fold increased risk of cardiovascular death, two principal mechanisms being: sudden, arrhythmic death associated with left ventricular hypertrophy, and ischaemic heart disease, associated with accelerated atherosclerosis. In recent years, the vascular endothelium has...

journal_title：Journal of nephrology

authors： Morris ST,Jardine AG

更新日期：2000-03-01 00:00:00

abstract：:Emphysematous pyelonephritis is a rare life-threatening infection of the renal parenchyma. It usually affects unilateral kidney and occurs mostly in diabetic patients. It is characterized by the presence of gas within the renal parenchyma and requires prompt diagnosis and early aggressive therapy. Bilateral emphysemat...

journal_title：Journal of nephrology

authors： Lim CS,Kim WB,Kim YS,Ahn C,Han JS,Kim S,Lee JS

更新日期：2000-03-01 00:00:00

abstract：:The term thin glomerular basement membrane disease (TBMD) refers to a condition characterised by thinning of the GBM at electron microscopy examination and, clinically, by isolated hematuria, frequently occurring in other family members, with no extra-renal manifestations. Progression towards chronic renal failure (CR...

journal_title：Journal of nephrology

authors： Frascá GM,Onetti-Muda A,Renieri A

更新日期：2000-01-01 00:00:00

abstract：:Sclerosing encapsulating peritonitis (SEP) is a serious complication of long-term continuous ambulatory peritoneal dialysis (CAPD), very likely related to a persisting expression of the transforming growth factor beta1 (TGFbeta1) gene on peritoneal mesothelial cells. We report the case of a 67-year-old uremic woman wh...

journal_title：Journal of nephrology

authors： Allaria PM,Giangrande A,Gandini E,Pisoni IB

更新日期：1999-11-01 00:00:00

abstract：:A widely diffused method to measure the reabsorption by single segments of the nephron in humans is based on water diuresis (WD), assuming that the peak urine flow rate approximates proximal delivery (PD). However, back-diffusion of an unknown volume of solute-free water (CH2O-BD) from lumen to the interstitium even i...

journal_title：Journal of nephrology

authors： Bartoli E,Romano G

更新日期：1999-09-01 00:00:00